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	Provedor de dados Genet. Mol. Biol. (1) Autor Fan,Jinyu (1) Li,Deming (1) Li,Ziwei (1) Xu,Cunshuan (1) Palavra-chave Epidermal growth factor (1) Liver regeneration (1) Methylation dynamics (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2014 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última DNA methylation dynamics in the rat EGF gene promoter after partial hepatectomy Genet. Mol. Biol. Li,Deming; Fan,Jinyu; Li,Ziwei; Xu,Cunshuan. Epidermal growth factor (EGF), a multifunctional growth factor, is a regulator in a wide variety of physiological processes. EGF plays an important role in the regulation of liver regeneration. This study was aimed at investigating the methylation level of EGF gene throughout liver regeneration. DNA of liver tissue from control rats and partial hepatectomy (PH) rats at 10 time points was extracted and a 354 bp fragment including 10 CpG sites from the transcription start was amplified after DNA was modified by sodium bisulfate. The result of sequencing suggested that methylation ratio of four CpG sites was found to be significantly changed when PH group was compared to control group, in particular two of them were extremely striking. mRNA expression of EGF... Tipo: Info:eu-repo/semantics/article Palavras-chave: Methylation dynamics; Epidermal growth factor; Liver regeneration. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000300017 Registros recuperados: 1 Primeira ... 1 ... Última

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