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| Fatani,A. J.; Al-Zuhair,H. A.; Yaquob,H. I.; Abdel-Fattah,A. A.; El-Sayed,M. I.; El-Sayed,F. A.. |
| Oxidative stress and proteases have been implicated in several diseases and extensive evidence indicates that antioxidants and protease inhibitors help prevent organ functional damage. Leiurus quinquestriatus (LQQ) scorpion venom causes cellular injuries that may lead to multiple organ failure. Thus, the capability of the antioxidant "natural standardized extract of Gingko biloba leaves (Gin, EGb 761)" and the non-selective protease inhibitor, aprotinin, in ameliorating venom-induced biochemical alterations indicative of cellular injury and oxidative stress was studied to determine their effectiveness in protecting rats from venom-evoked cellular damages. Thus, in this study, rats were treated with LQQ venom (0.3mg.kg-1, subcutaneously) alone or after Gin... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leiurusquinquestriatus; Ginkgo; Aprotinin; Scorpion venoms. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000200008 |
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| Abdoon,N. A.; Ali,A. A.; Alnema,A. A.; Hag-Ali,M.; Fatani,A. J.. |
| The cumulative actions of scorpion neurotoxins are complex and may be traced to activation of different ion channels with subsequent release of various transmitters and modulators including inflammatory mediators. This could lead to various pathological manifestations such as acute respiratory distress syndrome (ARDS), systemic inflammatory response syndrome (SIRS), and multiple organ failure (MOF). Several approaches have been advocated to treat the multitude of scorpion-venom-elicited pathological changes. However, few have tried to combat the venom-induced effects on the inflammatory process, which manifest as ARDS, SIDS and MOF. Thus, the aim of this study was to determine the capability of inhibitors of different steps of the inflammatory sequence of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leiurus quinquestriatus quinquestriatus; Scorpion venom; Acute respiratory distress syndrome; Systemic inflammatory response syndrome; Multiple organ failure; Montelukast; Hydrocortisone; Indomethacin. |
| Ano: 2006 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000300003 |
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| Al-Shanawani,A. R.; Fatani,A. J.; El-Sayed,F. H.. |
| Scorpion venom toxins generally produce similar effects by mainly acting on sodium channels, and to a lesser extent, on potassium, calcium, and chloride channels. This leads to increased release of neurotransmitters and mediators, resulting in a cascade of pathological events, involving the central nervous system, the autonomic nervous system, the cardiovascular and the respiratory system, eventually leading to death. The objective of this paper was to discover whether a sodium channel blocker, lidocaine, or a calcium channel blocker, verapamil, would prolong the survival of mice injected with the venom from the common yellow scorpion Leiurus quinquestriatus quinquestriatus (LQQ). For this purpose, mice were divided into 2 groups, each injected with a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Leiurus quinquestriatus quinquestriatus scorpion venom neurotoxins Na+ channels Ca2+ channels lidocaine; Verapamil mice lethality. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000200008 |
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