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Hepatoprotective effects of Iranian Hypericum scabrum essential oils against oxidative stress induced by acetaminophen in rats BABT
Dadkhah,Abolfazl; Fatemi,Faezeh; Farsani,Mohsen Eslami; Roshanaei,Kambiz; Alipour,Mahdi; Aligolzadeh,Hadi.
This studied examined the protective role of Hypericum scabrum oils (100 and 200 mg/kg b.w, i.p) on acetaminophen-induced liver damages in the rat. The hepatic oxidative/antioxidant parameters such as lipid peroxidation (LP), glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and ferric reducing ability of plasma (FRAP) were measured 2, 4, 8, 16 and 24h after the treatments confirmed by histopathological consideration. The results indicated that increased levels of hepatic LP and FRAP and SOD activity were reversed in the rats treated with oils. In addition, the depleted GSH were compensated with the oil treatments. The protective effect of the oils was further confirmed by the histophatological examination carried out on liver biopsies. The...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypericum scabrum; Essential oils; Acetaminophen; Rat; Oxidative stress; Liver.
Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000300005
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Evaluation of Gamma Irradiation Effect on the Oxidative Stress Factors in Septic Rats Treated With Iranian Plant Essential Oils BABT
Fatemi,Faezeh; Yazdi,Atefeh Jalali; Ghanooni,Shirin; Zolfaghari,Mohammad Reza.
ABSTRACT Cuminum cyminum L. (CM), Zataria multiflora Boiss. (ZM) and Mentha piperita L. (MP) are traditional medicinal plants with various pharmacological properties. This study was designed to assess the role of gamma irradiation -a modern decontamination method- in hepatoprotective effects of their essential oil (E.Os) in septic rats induced by experimental cecal ligation and puncture (CLP) model. The rats were divided into 20 groups; sham-operated (SOP); CLP; CLP + CM, ZM and MP (E.Os) (100 & 200 mg/kg b.w) and CLP + gamma irradiated (10 and 25 kGy) E.Os (100 & 200 mg/kg b.w) as treatment groups. All E.Os were injected i.p immediately after sepsis induction. 24 hour after CLP, the rats were sacrificed and the liver tissue was examined...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Essential oils; Oxidative stress; Antioxidant; CLP; Gamma irradiation.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100312
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