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Irradiation effects on antibody performance in the frame of biochip-based instruments development for space exploration ArchiMer
Baque, M.; Dobrijevic, M.; Le Postollec, A.; Moreau, T.; Faye, C.; Vigier, F.; Incerti, S.; Coussot, G.; Caron, J.; Vandenabeele Trambouze, Odile.
Several instruments based on immunoassay techniques have been proposed for life-detection experiments in the framework of planetary exploration but few experiments have been conducted so far to test the resistance of antibodies against cosmic ray particles. We present several irradiation experiments carried out on both grafted and free antibodies for different types of incident particles (protons, neutrons, electrons and C-12) at different energies (between 9 MeV and 50 MeV) and different fluences. No loss of antibodies activity was detected for the whole set of experiments except when considering protons with energy between 20 and 30 MeV (on free and grafted antibodies) and fluences much greater than expected for a typical planetary mission to Mars for...
Tipo: Text Palavras-chave: Astrobiology; Biochip; Cosmic rays; Search for extraterrestrial life.
Ano: 2017 URL: http://archimer.ifremer.fr/doc/00366/47678/47809.pdf
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