|
|
|
|
|
| Asad,Nasser Ribeiro; Asad,Lidia Maria Buarque Oliveira; Almeida,Carlos Eduardo Bonacossa de; Felzenszwalb,Israel; Cabral-Neto,Januário Bispo; Leitão,Alvaro Costa. |
| Hydrogen peroxide is an important reactive oxygen species (ROS) that arises either during the aerobic respiration process or as a by-product of water radiolysis after exposure to ionizing radiation. The reaction of hydrogen peroxide with transition metals imposes on cells an oxidative stress condition that can result in damage to cell components such as proteins, lipids and principally to DNA, leading to mutagenesis and cell death. Escherichia coli cells are able to deal with these adverse events via DNA repair mechanisms, which enable them to recover their genome integrity. These include base excision repair (BER), nucleotide excision repair (NER) and recombinational repair. Other important defense mechanisms present in Escherichia coli are OxyR and SosRS... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hydrogen peroxide; Cross-adaptive response; Lethal synergism; Copper and iron. |
| Ano: 2004 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000200026 |
| |
|
|
| Rainho,Claudia R. de; Kaezer,Andréa; Aiub,Claudia A.F.; Felzenszwalb,Israel. |
| N-nitroso compounds, such as N-nitrosodiethylamine (NDEA), can be formed by the reaction of secundary amines with nitrosating agents, and are suspected to be involved in tumors in humans. NDEA has been considered a weak carcinogen in genotoxic assays probably due to the inefficient nitrosamine activation system that is used and/or to the efficient repair system. In this work, we evaluated the sensibility of Allium cepa L. root tips and Tradescantia stamen hair mutation assay (Trad-SH) using Tradescantia pallida var. purpurea for NDEA (0.1; 0.5; 5 and 25mM) genotoxicity and mutagenicity induction. Allium cepa L. was treated with different NDEA concentrations for 3h, for 3 consecutive days, including negative control (distilled water) and positive control... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Allium cepa; Genotoxicity; Mutagenicity; N-nitrosodiethylaine; Tradescantia pallida var. purpurea. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000400015 |
| |
|
|
|
