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Faster gastric emptying of a liquid meal in rats after hypothalamic dorsomedial nucleus lesion BJMBR
Denofre-Carvalho,S.; Collares,E.F.; Fernandes,G.A..
The effects of dorsomedial hypothalamic (DMH) nucleus lesion on body weight, plasma glucose levels, and the gastric emptying of a liquid meal were investigated in male Wistar rats (170-250 g). DMH lesions were produced stereotaxically by delivering a 2.0-mA current for 20 s through nichrome electrodes (0.3-mm tip exposure). In a second set of experiments, the DMH and the ventromedial hypothalamic (VMH) nucleus were lesioned with a 1.0-mA current for 10 s (0.1-mm tip exposure). The medial hypothalamus (MH) was also lesioned separately using a nichrome electrode (0.3-mm tip exposure) with a 2.0-mA current for 20 s. Gastric emptying was measured following the orogastric infusion of a liquid test meal consisting of physiological saline (0.9% NaCl, w/v) plus...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Gastric emptying; Hypothalamus; Dorsomedial nucleus.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000900011
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Serum cytokine levels in autoimmune and non-autoimmune hyperthyroid states BJMBR
Ward,L.S.; Fernandes,G.A..
Although the role of interleukin-2 (IL-2) and interferon gamma (<FONT FACE="Symbol">g</FONT>IFN) is still poorly understood in hyperthyroid diseases, it is reasonable to assume that these cytokines may be present at higher levels in Graves' disease (GD) than in other primarily non-autoimmune thyroid diseases. In order to look for an easy method to distinguish GD from primarily non-autoimmune causes of hyperthyroidism, we compared 13 healthy individuals with 21 treated and untreated hyperthyroid GD patients and with 19 patients with hyperthyroidism due to other etiologies: 7 cases of multinodular goiter, 5 cases of excessive hormone replacement and 7 cases of amiodarone-associated hyperthyroidism. All patients presented low TSH levels and a...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Cytokines; IL-2; Hyperthyroidism; Graves' disease; Diagnosis.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000100009
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The influence of septal lesions on sodium and water retention induced by Walker 256 tumor BJMBR
Guimarães,F.; Rettori,O.; Vieira-Matos,A.N.; Fernandes,G.A..
In the course of studies on the effects of septal area lesions on neuroimmunomodulation and Walker 256 tumor development, it was observed that tumor-induced sodium and water retention was less marked in lesioned than in non-lesioned rats. In the present study possible mechanisms involved in this phenomenon were investigated. The experiments were performed in septal-lesioned (LW; N = 15) and sham-operated (SW; N = 7) 8-week-old male Wistar rats, which received multifocal simultaneous subcutaneous (sc) inoculations of Walker 256 tumor cells about 30 days after the stereotaxic surgery. Control groups (no tumor, sham-operated food-restricted (SFR), N = 7) and lesioned food-restricted (LFR, N = 10) were subjected to a feeding pattern similar to that observed in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Na+ retention; Secondary diuretic response; Tumor systemic effects; Septal area lesion; Multifocal tumor inoculation; Walker 256 tumor.
Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000300010
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