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Regulation of adipogenesis by nucelar receptor PPARγ is modulated by the histone demethylase JMJD2C Genet. Mol. Biol.
Fernando,Lizcano; Carolina,Romero; Vargas,Diana.
A potential strategy to combat obesity and its associated complications involves modifying gene expression in adipose cells to reduce lipid accumulation. The nuclear receptor Peroxisome Proliferator-activated receptor gamma (PPARγ) is the master regulator of adipose cell differentiation and its functional activation is currently used as a therapeutic approach for Diabetes Mellitus type 2. However, total activation of PPARγ induces undesirable secondary effects that might be set with a partial activation. A group of proteins that produce histone demethylation has been shown to modify the transcriptional activity of nuclear receptors. Here we describe the repressive action of the jumonji domain containing 2C/lysine demethylase 4 C (JMJD2C/KDM4C) on PPARγ...
Tipo: Info:eu-repo/semantics/article Palavras-chave: PPARγ; Histones; Demethylation; JMJD2C; Deacetylation; Adipocyte; Trichostatin A.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000100004
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