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Gut permeability to lactulose and mannitol differs in treated Crohn's disease and celiac disease patients and healthy subjects BJMBR
Vilela,E.G.; Torres,H.O.G.; Ferrari,M.L.A.; Lima,A.S.; Cunha,A.S..
The gut barrier monitors and protects the gastrointestinal tract from challenges such as microorganisms, toxins and proteins that could act as antigens. There is evidence that gut barrier dysfunction may act as a primary disease mechanism in intestinal disorders. The aim of the present study was to evaluate the barrier function towards sugars after the appropriate treatment of celiac disease and Crohn's disease patients and compare the results with those obtained with healthy subjects. Fifteen healthy volunteers, 22 celiac disease patients after 1 year of a gluten-free diet, and 31 Crohn's disease patients in remission were submitted to an intestinal permeability test with 6.0 g lactulose and 3.0 g mannitol. Six-hour urinary lactulose excretion in Crohn's...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Intestinal permeability; Celiac disease; Crohn's disease; Mannitol; Lactulose.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001200010
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