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	Provedor de dados BJPS (2) Autor Ferrari,Priscileila Colerato (2) Almeida,Marina Penteado de (1) Farago,Paulo Vitor (1) Klein,Traudi (1) Langoski,Gisele (1) Lopes,Clarissa Elize (1) Nohemann,Laís (1) Mais... Palavra-chave Chitosan (1) Controlled drug delivery. (1) Ethylcellulose (1) Floating microparticle (1) Halcinonide/encapsulation efficiency (1) Halcinonide/quantification (1) High performance liquid chromatography/method validation (1) Hydroxypropyl methylcellulose (1) Polymeric lipid-core nanoparticles (1) Solid lipid nanoparticles (1) Topical administration (1) Toxicity (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2017 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última A simple HPLC method for the determination of halcinonide in lipid nanoparticles: development, validation, encapsulation efficiency, and in vitro drug permeation BJPS Lopes,Clarissa Elize; Langoski,Gisele; Klein,Traudi; Ferrari,Priscileila Colerato; Farago,Paulo Vitor. ABSTRACT Halcinonide is a high-potency topical glucocorticoid used for skin inflammation treatments that presents toxic systemic effects. A simple and quick analytical method to quantify the amount of halcinonide encapsulated into lipid nanoparticles, such as polymeric lipid-core nanoparticles and solid lipid nanoparticles, was developed and validated regarding the drug's encapsulation efficiency and in vitro permeation. The development and validation of the analytical method were carried out using the high performance liquid chromatography with the UV detection at 239 nm. The validation parameters were specificity, linearity, precision and accuracy, limits of detection and quantitation, and robustness. The method presented an isocratic flow rate of 1.0... Tipo: Info:eu-repo/semantics/article Palavras-chave: Halcinonide/encapsulation efficiency; Halcinonide/quantification; Polymeric lipid-core nanoparticles; Solid lipid nanoparticles; Topical administration; Toxicity; High performance liquid chromatography/method validation. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200604 Floating ability and drug release evaluation of gastroretentive microparticles system containing metronidazole obtained by spray drying BJPS Nohemann,Laís; Almeida,Marina Penteado de; Ferrari,Priscileila Colerato. Abstract Gastroretentive floating microparticles were developed and evaluated for the controlled metronidazole delivery for treatment of gastric disease. Floating microparticles, varying in proportions of chitosan and hydroxypropyl methylcellulose or ethylcellulose, were obtained by spray drying. Floating microparticles were characterized by physicochemical and in vitro studies, according to their floating ability and drug delivery. Microparticles presented mean diameter from 1.05 to 2.20 µm. The infrared spectroscopy confirmed the drug encapsulation and showed no chemical linkage between microparticles components. X-ray diffraction showed changes in the drug`s solid state, from crystalline to amorphous, indicating partial drug encapsulation, due to the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Floating microparticle; Chitosan; Ethylcellulose; Hydroxypropyl methylcellulose; Controlled drug delivery.. Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000100611 Registros recuperados: 2 Primeira ... 1 ... Última

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