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| Magalhães,Hemerson I.F.; Ferreira,Paulo M.P.; Moura,Eraldo S.; Torres,Márcia R.; Alves,Ana P.N.N.; Pessoa,Otília D.L.; Costa-Lotufo,Letícia V.; Moraes,Manoel O.; Pessoa,Cláudia. |
| The cytotoxic potential of stem organic extracts from Calotropis procera (Asclepiadaceae) was firstly evaluated against cancer cell lines by MTT assay. Subsequently, samples considered cytotoxic were tested for antimitotic activity on sea urchin egg development and for in vivo antiproliferative activity in mice bearing Sarcoma 180 tumor. Among the five extracts (hexane, dichloromethane, ethyl acetate, acetone and methanol), ethyl acetate and acetone extracts displayed higher cytotoxic potential against tumor cells, with IC50 ranging from 0.8 to 4.4 μg/mL, while methanolic extract was weakly cytotoxic. Cytotoxic extracts also exhibited cell division inhibition capacity by antimitotic assay, revealing IC50 values lower than 5 μg/mL. In the in vivo antitumor... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antimitotic; Antiproliferative; Calotropis procera; Sarcoma 180 tumor; Stem extracts. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000200017 |
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| Ferreira,Paulo M.P.; Carvalho,Ana F.U.; Farias,Davi F.; Cariolano,Nara G.; Melo,Vânia M.M.; Queiroz,Maria G.R.; Martins,Alice M.C.; Machado-Neto,Joaquim G.. |
| In this work, biological effects of the water extract of Moringa oleifera seeds (WEMOS) were assessed on eggs and 3rd instar larvae of Aedes aegypti and on its toxicity upon laboratory animals (Daphnia magna, mice and rats). Crude WEMOS showed a LC50 value of 1260µg/mL, causing 99.2 ± 2.9% larvae mortality within 24 h at 5200µg/mL, though this larvicidal activity has been lost completely at 80ºC/10 min. WEMOS did not demonstrate capacity to prevent egg hatching. After extensive dialyses of the crude WEMOS into watersoluble dialyzable (DF) and nondyalizable (NDF) fractions, only DF maintained its efficacy to kill larvae. Acute toxicity evaluations on daphnids (EC50 of 188.7µg/mL) and mice (LD50 of 446.5 mg/kg body weight) pointed out to low toxicity.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Aedes aegypti; Daphnia magna; Larvicidal activity; Moringa oleifera seeds; Toxicity. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000200007 |
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