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| Ferreira,Paulo Michel P.; Costa-Lotufo,Leticia V.; Moraes,Manoel O.; Barros,Francisco W.A.; Martins,Aline M.A.; Cavalheiro,Alberto J.; Bolzani,Vanderlan S.; Santos,Andre G.; Pessoa,Claudia. |
| Folk uses and scientific investigations have highlighted the importance of Casearia sylvestris extracts and their relevant bioactive potential. The aim of this work was to review the pharmacological properties of C. sylvestris, emphasizing its anti-ulcer, anti-inflammatory, anti-ophidian and antitumor potentialities. Ethanolic extracts and essential oil of their leaves have antiulcerogenic activity and reduce gastric volume without altering the stomach pH, which corroborates their consumption on gastrointestinal disorders. Leaf water extracts show phospholipase A2 inhibitory activity that prevents damage effects on the muscular tissue after toxin inoculation. This antiphospholipasic action is probably related to the use as an anti-inflammatory, proposing a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Casearia sylvestris; Folk uses; Pharmacological properties. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000400024 |
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| Ferreira,Paulo Michel P.; Farias,Davi F.; Viana,Martônio P.; Souza,Terezinha M.; Vasconcelos,Ilka M.; Soares,Bruno M.; Pessoa,Cláudia; Costa-Lotufo,Letícia V.; Moraes,Manoel O.; Carvalho,Ana F.U.. |
| This study assessed the antiproliferative and cytotoxic potential against tumor lines of ethanolic seed extracts of 21 plant species belonging to different families from Northeastern Brazil. In addition, some underlying mechanisms involved in this cytotoxicity were also investigated. Among the 21 extracts tested, the MTT assay after 72 h of incubation demonstrated that only the ethanolic extract obtained from Myracrodruon urundeuva seeds (EEMUS), which has steroids, alkaloids and phenols, showed in vitro cytotoxic activity against human cancer cells, being 2-fold more active on leukemia HL-60 line [IC50 value of 12.5 (9.5-16.7) μg/mL] than on glioblastoma SF-295 [IC50 of 25.1 (17.3-36.3) μg/mL] and Sarcoma 180 cells [IC50 of 38.1 (33.5-43.4) μg/mL]. After... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antiproliferative potential; Northeastern Brazilian plants; Myracrodruon urundeuva; Sarcoa 180 tumor; Seed extracts. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000300023 |
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