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| Ferreira-Neto,Marcos L.; Possas,Olga S.; Lopes,Oswaldo U.; Cravo,Sérgio L.. |
| Electrical stimulation of the hypothalamus produces cardiovascular adjustments consisting of hypertension, tachycardia, visceral vasoconstriction and hindlimb vasodilation. Previous studies have demonstrated that hindlimb vasodilation is due a reduction of sympathetic vasoconstrictor tone and to activation of beta2-adrenergic receptors by catecholamine release. However, the existence of a yet unidentified vasodilator mechanism has also been proposed. Recent studies have suggested that nitric oxide (NO) may be involved. The aim of the present study was to investigate the role of NO in the hindquarter vasodilation in response to hypothalamic stimulation. In pentobarbital-anesthetized rats hypothalamic stimulation (100 Hz, 150µA, 6 s) produced hypertension,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hindlimb blood flow; Hypothalamus; Electrical stimulation; Defense reaction. |
| Ano: 2005 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652005000200005 |
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| Cravo,Sergio L.; Campos,Ruy R.; Colombari,Eduardo; Sato,Mônica A.; Bergamaschi,Cássia M.; Pedrino,Gustavo R.; Ferreira-Neto,Marcos L.; Lopes,Oswaldo U.. |
| Several forms of experimental evidence gathered in the last 37 years have unequivocally established that the medulla oblongata harbors the main neural circuits responsible for generating the vasomotor tone and regulating arterial blood pressure. Our current understanding of this circuitry derives mainly from the studies of Pedro Guertzenstein, a former student who became Professor of Physiology at UNIFESP later, and his colleagues. In this review, we have summarized the main findings as well as our collaboration to a further understanding of the ventrolateral medulla and the control of arterial blood pressure under normal and pathological conditions. |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hypertension; Baroreceptor reflexes; Vasomotor nuclei; Sympathetic nerve activity; Arterial pressure. |
| Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300021 |
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