|
|
|
|
|
| Silva-Alves,K.S.; Ferreira-da-Silva,F.W.; Peixoto-Neves,D.; Viana-Cardoso,K.V.; Moreira-Júnior,L.; Oquendo,M.B.; Oliveira-Abreu,K.; Albuquerque,A.A.C.; Coelho-de-Souza,A.N.; Leal-Cardoso,J.H.. |
| Estragole is a volatile terpenoid, which occurs naturally as a constituent of the essential oils of many plants. It has several pharmacological and biological activities. The objective of the present study was to investigate the mechanism of action of estragole on neuronal excitability. Intact and dissociated dorsal root ganglion neurons of rats were used to record action potential and Na+ currents with intracellular and patch-clamp techniques, respectively. Estragole blocked the generation of action potentials in cells with or without inflexions on their descendant (repolarization) phase (Ninf and N0 neurons, respectively) in a concentration-dependent manner. The resting potentials and input resistances of Ninf and N0 cells were not altered by estragole... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Estragole; Local anesthetic; Essential oil; Dorsal root ganglia; Phenylpropanoid; Na+ current. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001201056 |
| |
|
|
| Sousa,D.G.; Sousa,S.D.G.; Silva,R.E.R.; Silva-Alves,K.S.; Ferreira-da-Silva,F.W.; Kerntopf,M.R.; Menezes,I.R.A.; Leal-Cardoso,J.H.; Barbosa,R.. |
| Lippia alba is empirically used for infusions, teas, macerates, and hydroalcoholic extracts because of its antispasmodic, analgesic, sedative, and anxiolytic effects. Citral is a mixture of trans-geranial and cis-neral and is the main constituent of L. alba essential oil and possesses analgesic, anxiolytic, anticonvulsant, and sedative effects. The present study evaluated the effects of the essential oil of L. alba (EOLa) and citral on compound action potentials (CAPs) in Wistar rat sciatic nerves. Both drugs inhibited CAP in a concentration-dependent manner. The calculated half-maximal inhibitory concentrations (IC50) of peak-to-peak amplitude were 53.2 µg/mL and 35.00 µg/mL (or 230 µM) for EOLa and citral, respectively. Peak-to-peak amplitude of the CAP... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Citral; Nerve excitability; Lippia alba; Sciatic nerve; Essential oil; Compound action potential. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000800697 |
| |
|
|
| Coelho-de-Souza,A.N.; dos-Santos,C.F.; Lopes-Filho,L.N.; Holanda,F.R.; Oliveira,A.C.; Gomes-Vasconcelos,Y.A.; Oliveira,K.A.; Ferreira-da-Silva,F.W.; Silva-Alves,K.S.; Leal-Cardoso,J.H.. |
| Essential oils (EO) are volatile liquids responsible for the aroma of plants. Pterodon polygalaeflorus seeds have received widespread use in folk medicine for the treatment of inflammatory diseases. For this reason and because Pterodon polygalaeflorus seeds have great EO content, which is frequently pharmacologically active, the present study aimed to evaluate the antinociceptive effect of EO from Pterodon polygalaeflorus (EOPPgfl) and its acute toxic effects. The EEOPPgfl sample, which was extracted by steam distillation of the seeds, had a yield of 2.4% of the seeds weight and had, as major constituents, beta-elemene (48.19%), trans-caryophyllene (19.51%), and epi-bicyclosesquiphellandrene (12.24%). The EOPPgfl sample showed mild acute toxicity and its... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Essential oil; Pterodon polygalaeflorus; Antinociception; Anti-inflammatory activities; Beta-elemene; Caryophyllene. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018001100603 |
| |
|
|
| Barbosa,R.; Cruz-Mendes,Y.; Silva-Alves,K.S.; Ferreira-da-Silva,F.W.; Ribeiro,N.M.; Morais,L.P.; Leal-Cardoso,J.H.. |
| Lippia sidoides Cham is a typical herb species of Northeast Brazil with widespread use in folk medicine. The major constituents of the essential oil of L. sidoides (EOLs) are thymol, p-cymene, myrcene, and caryophyllene. Several studies have shown that the EOLs and its constituents have pharmacological effects, including antibacterial, anti-inflammatory, antioxidant and neuroprotective activity. Therefore, this work aimed to investigate the effects of the EOLs and their main constituents on rat sciatic nerve excitability. The sciatic nerves of adult Wistar rats were dissected and mounted in a moist chamber. Nerves were stimulated by square wave pulses, with an amplitude of 40 V, duration of 100 μs to 0.2 Hz. Both EOLs and thymol inhibited compound action... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Compound action potential; Essential oil; Lippia sidoides; Thyme oil; P-cymene; Myrcene. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001200611 |
| |
|
|
|
