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| Silva,Gisele Rodrigues da; Fialho,Sílvia Ligório; Siqueira,Rubens Camargo; Jorge,Rodrigo; Cunha Júnior,Armando da Silva. |
| The treatment of diseases affecting the posterior segment of the eye is limited by the difficulty in transporting effective doses of drugs to the vitreous, retina, and choroid. Topically applied drugs are poorly absorbed due to the low permeability of the external ocular tissues and tearing. The blood-retina barrier limits drug diffusion from the systemic blood to the posterior segment, thus high doses of drug are needed to maintain therapeutic levels. In addition, systemic side effects are common. Intraocular injections could be an alternative, but the fast flowing blood supply in this region, associated with rapid clearance rates, causes drug concentration to quickly fall below therapeutic levels. To obtain therapeutic levels over longer time periods,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Implants/biodegradation; Drugs/delivery systems; Drugs/prolonged delivery systems; Pharmaceutical technology. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502010000300024 |
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| Bastos,Leandro Francisco Silva; Vago,Juliana Priscila; Caux,Thaís Rolla; Costa,Bruna Lopes; Godin,Adriana Martins; Menezes,Raquel Rezende; Pena,Roberta Ribas; Silva-Cunha,Armando; Sousa,Lirlândia Pires; Machado,Renes Resende; Moraes,Márcio Flávio Dutra; Fialho,Sílvia Ligório; Coelho,Márcio Matos. |
| Neuroimmune interactions underlying the development of pain sensitization in models of neuropathic pain have been widely studied. In this study, we evaluated the development of allodynia and its reduction associated with peripheral antineuroinflammatory effects induced by a dexamethasone-loaded biodegradable implant. Chronic constriction injury (CCI) of the sciatic nerve was performed in Wistar rats. The electronic von Frey test was applied to assess mechanical allodynia. The dexamethasone-loaded implant was placed perineurally at the moment of CCI or 12 days after surgery. Dorsal root ganglia (DRG; L4-L5) were harvested and nuclear extracts were assayed by Western blot for detection of nuclear factor (NF)-κB p65/RelA translocation. Dexamethasone delivered... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Chronic Constriction Injury; Dexamethasone/ pharmacology; Delivery device; Neuropathic Pain/ chemically induced; Nuclear Factor kappa B/ drug effects; Neuralgia/ chemically induced; NF-kappa B/ drug effects; Sciatic Nerve/ injuries; Absorbable Implants/ trends. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100591 |
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