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In silico prediction of potential allergenicity of proteins according to the FAO/WHO guidelines with the help of Allermatch-TM Frontis
Fiers, M.W.E.J.; Kleter, G.A.; Peijnenburg, A.A.C.M.; Nijland, H.; Nap, J.P.; Van Ham, R.C.H.J..
AllermatchTM (http://allermatch.org) is a novel web tool for the efficient and standardized prediction of potential allergenicity of proteins according to the current recommendations of the FAO/WHO Expert Consultation, as outlined in the Codex alimentarius. A query amino-acid sequence is compared against the Allermatch- Allergen database based on current SwissProt and WHO-IUIS allergen lists. The web tool uses a sliding window to identify stretches of 80 amino acids with more than 35% similarity, or identical small stretches of at least six amino acids. The outcome of the analyses is presented in a concise format. AllermatchTM is likely to contribute to improved, transparent and more consistent analyses of potential allergenicity of genetically modified...
Tipo: Conference proceedings
Ano: 2005 URL: http://library.wur.nl/ojs/index.php/frontis/article/view/1068
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