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	Provedor de dados BJMBR (3) Autor Forte,L.R. (3) Carrithers,S.L. (1) Carvalho,A.F. (1) Fonteles,M.C. (1) Freeman,R.H. (1) Giannella,R.A. (1) Greenberg,R.N. (1) Hill,M.J. (1) Jackson,B.A. (1) Johnson,B.R. (1) Krause,W.J. (1) London,R.M. (1) Lorenz,J. (1) Mann,E.A. (1) O'Hara,S.M. (1) Ott,C.E. (1) Santos-Neto,M.S. (1) Mais... Palavra-chave Kidney (3) Natriuresis (2) ANP (1) CGMP (1) Chloride secretion (1) Differential display PCR (1) Guanylate cyclase (1) Guanylin (1) Guanylyl cyclase C (1) Heat-stable enterotoxin (1) Intestine (1) Sodium excretion (1) Sodium-potassium ATPase (1) Uroguanylin (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 1999 (3) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Renal effects of uroguanylin and guanylin in vivo BJMBR Carrithers,S.L.; Hill,M.J.; Johnson,B.R.; O'Hara,S.M.; Jackson,B.A.; Ott,C.E.; Lorenz,J.; Mann,E.A.; Giannella,R.A.; Forte,L.R.; Greenberg,R.N.. Uroguanylin and guanylin are newly discovered endogenous heat-stable peptides that bind to and activate a membrane bound guanylyl cyclase signaling receptor (termed guanylyl cyclase C; GC-C). These peptides are not only found in blood but are secreted into the lumen of the intestine and effect a net secretion of electrolytes (Na+, K+, Cl-, HCO3-) and fluid into the intestine via a cyclic guanosine-3',5'-monophosphate (cGMP) mechanism. GC-C is also the receptor for Escherichia coli heat-stable enterotoxin (STa) and activation by STa results in a diarrheal illness. Employing mouse renal in vivo models, we have demonstrated that uroguanylin, guanylin, and STa elicit natriuretic, kaliuretic, and diuretic effects. These biological responses are time- and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Guanylyl cyclase C; Heat-stable enterotoxin; Kidney; Natriuresis; Sodium-potassium ATPase; Differential display PCR. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100003 Guanylin peptides: cyclic GMP signaling mechanisms BJMBR Forte,L.R.; Freeman,R.H.; Krause,W.J.; London,R.M.. Guanylate cyclases (GC) serve in two different signaling pathways involving cytosolic and membrane enzymes. Membrane GCs are receptors for guanylin and atriopeptin peptides, two families of cGMP-regulating peptides. Three subclasses of guanylin peptides contain one intramolecular disulfide (lymphoguanylin), two disulfides (guanylin and uroguanylin) and three disulfides (E. coli stable toxin, ST). The peptides activate membrane receptor-GCs and regulate intestinal Cl- and HCO3- secretion via cGMP in target enterocytes. Uroguanylin and ST also elicit diuretic and natriuretic responses in the kidney. GC-C is an intestinal receptor-GC for guanylin and uroguanylin, but GC-C may not be involved in renal cGMP pathways. A novel receptor-GC expressed in the opossum... Tipo: Info:eu-repo/semantics/article Palavras-chave: Kidney; Intestine; Guanylate cyclase; Chloride secretion; Sodium excretion. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001100002 Relationship between the actions of atrial natriuretic peptide (ANP), guanylin and uroguanylin on the isolated kidney BJMBR Santos-Neto,M.S.; Carvalho,A.F.; Forte,L.R.; Fonteles,M.C.. Guanylin and uroguanylin are peptides that bind to and activate guanylate cyclase C and control salt and water transport in many epithelia in vertebrates, mimicking the action of several heat-stable bacteria enterotoxins. In the kidney, both of them have well-documented natriuretic and kaliuretic effects. Since atrial natriuretic peptide (ANP) also has a natriuretic effect mediated by cGMP, experiments were designed in the isolated perfused rat kidney to identify possible synergisms between ANP, guanylin and uroguanylin. Inulin was added to the perfusate and glomerular filtration rate (GFR) was determined at 10-min intervals. Sodium was also determined. Electrolyte dynamics were measured by the clearance formula. Guanylin (0.5 µg/ml, N = 12) or uroguanylin... Tipo: Info:eu-repo/semantics/article Palavras-chave: ANP; Guanylin; Uroguanylin; Kidney; Natriuresis; CGMP. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000800012 Registros recuperados: 3 Primeira ... 1 ... Última

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