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| Siqueira,E.R.F.; Oliveira,C.P.M.S.; Correa-Giannella,M.L.; Stefano,J.T.; Cavaleiro,A.M.; Fortes,M.A.H.Z.; Muniz,M.T.C.; Silva,F.S.; Pereira,L.M.M.B.; Carrilho,F.J.. |
| The reduction of hepatic microsomal transfer protein (MTP) activity results in fatty liver, worsening hepatic steatosis and fibrosis in chronic hepatitis C (CHC). The G allele of the MTP gene promoter, -493G/T, has been associated with lower transcriptional activity than the T allele. We investigated this association with metabolic and histological variables in patients with CHC. A total of 174 untreated patients with CHC were genotyped for MTP -493G/T by direct sequencing using PCR. All patients were negative for markers of Wilson’s disease, hemochromatosis and autoimmune diseases and had current and past daily alcohol intake lower than 100 g/week. The sample distribution was in Hardy-Weinberg equilibrium. Among subjects with genotype 1, 56.8% of the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hepatitis C; Steatosis; Fibrosis; Microsomal transfer protein. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000100012 |
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| Murat,C.B.; Braga,P.B.S.; Fortes,M.A.H.Z.; Bronstein,M.D.; Corrêa-Giannella,M.L.C.; Giorgi,R.R.. |
| The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding the role of the gene in cell proliferation and survival through activation of the PI3K/Akt signaling pathway. Only one Chinese study described somatic mutations and amplification of the PIK3CA gene in a large series of pituitary adenomas. The aim of the present study was to determine genetic alterations of PIK3CA in a second series that consisted of 33 pituitary adenomas of different subtypes diagnosed by immunohistochemistry: 6 adrenocorticotropic hormone-secreting microadenomas, 5 growth hormone-secreting macroadenomas, 7 prolactin-secreting... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Pituitary adenomas; PIK3CA proto-oncogene; Genomic amplification; Somatic mutation. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000900009 |
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