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| Kohatsu,Andréa A.N.; Silva,Flávia A.J.; Francisco,Acácio I.; Rimoldi,Aline; Silva,Marco T.A.; Vargas,Maria D.; Rosa,João A. da; Cicarelli,Regina M.B.. |
| Abstract Resistance to benznidazole in certain strains of Trypanosoma cruzi may be caused by the increased production of enzymes that act on the oxidative metabolism, such as mitochondrial tryparedoxin peroxidase which catalyses the reduction of peroxides. This work presents cytotoxicity assays performed with ferrocenyl diamine hydrochlorides in six different strains of T. cruzi epimastigote forms (Y, Bolivia, SI1, SI8, QMII, and SIGR3). The last four strains have been recently isolated from triatominae and mammalian host (domestic cat). The expression of mitochondrial tryparedoxin peroxidase was analyzed by the Western blotting technique using polyclonal antibody anti mitochondrial tryparedoxin peroxidase obtained from a rabbit immunized with the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Trypanosoma cruzi; Ferrocenyl diamine hydrochlorides; Mitochondrial tryparedoxin peroxidase (mTcTXNPx); Oxidative stress mechanisms. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200125 |
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