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| Foltran,R.K.; Amorim,P.V.G.H.; Duarte,F.H.; Grande,I.P.P.; Freire,A.C.T.B.; Frassetto,F.P.; Dettoni,J.B.; Alves,V.A.; Castro,I.; Trarbach,E.B.; Bronstein,M.D.; Jallad,R.S.. |
| Genetic and functional aberrations of guanine nucleotide-binding protein, alpha stimulating (GNAS), aryl hydrocarbon receptor interacting protein (AIP), and pituitary tumor transforming gene (PTTG) are among the most prominent events in pituitary tumorigenesis. A cohort of Brazilian patients with somatotropinomas (n=41) and non-functioning pituitary adenomas (NFPA, n=21) from a single tertiary-referral center were evaluated for GNAS and AIP mutations and gene expression of AIP and PTTG. Results were compared to the clinical and biological (Ki67 and p53 expression) characteristics of tumors and their response to therapy, if applicable. Genetic analysis revealed that 27% of somatotropinomas and 4.8% of NFPA harbored GNAS mutations (P=0.05). However, no... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Somatotropinomas; Non-functioning pituitary adenomas; PTTG; AIP; GNAS1. |
| Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2018000900601 |
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