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	Provedor de dados BJPS (2) Autor Aragão,Cícero Flávio Soares (2) Freire,Fátima Duarte (2) Câmara,Manuela Bernardo (1) Dantas,Monique Gomes (1) Goes,Janaina da Silva (1) Lima e Moura,Túlio Flávio Accioly de (1) Moura,Túlio Flávio Accioly de Lima e (1) Raffin,Fernanda Nervo (1) Raffin,Fernanda Nervo (1) Mais... Palavra-chave Acrycoat L 100(r)/use/enteric coating (1) Captopril/ pharmacokinetics (1) Degradation Kinetics (1) Dosage Forms (1) Drug Compounding/ utilization (1) Drug Dosage Calculations (1) Drug Stability (1) Drug Utilization (1) Enzyme Stability/drug effects (1) Excipients/ pharmacokinetics (1) Gastric-resistant isoniazids/pellets (1) Kinetics (1) Pediatric Formulation (1) Pellets/enteric coating (1) Rifampicin (1) Thermal Analysis (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2019 (1) 2014 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Gastric-resistant isoniazid pellets reduced degradation of rifampicin in acidic medium BJPS Freire,Fátima Duarte; Câmara,Manuela Bernardo; Dantas,Monique Gomes; Aragão,Cícero Flávio Soares; Lima e Moura,Túlio Flávio Accioly de; Raffin,Fernanda Nervo. Isoniazid and rifampicin are considered the first-line medication for preventing and treating tuberculosis. Rifampicin is degraded in the stomach acidic environment, especially when combined with isoniazid, factor contributing to treatment failure. In this study, gastric-resistant isoniazid pellets were obtained to physical contact of this drug with rifampicin and to bypass the stomach´s acidic environment. The pellets were fabricated using the extrusion-spheronization technique. The coating process was conducted in a fluid spray coater using Acrycoat L 100(r) solution as the coating agent. The pellets obtained were submitted to a dissolution test in HCl 0.1 N and phosphate buffer media. The results indicated that optimum gastric-resistance was only... Tipo: Info:eu-repo/semantics/article Palavras-chave: Rifampicin; Gastric-resistant isoniazids/pellets; Pellets/enteric coating; Acrycoat L 100(r)/use/enteric coating. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000400749 Preformulation of a liquid dosage formulation of captopril for pediatric use: drug-excipient compatibility and stability studies BJPS Goes,Janaina da Silva; Freire,Fátima Duarte; Moura,Túlio Flávio Accioly de Lima e; Aragão,Cícero Flávio Soares; Raffin,Fernanda Nervo. Currently, medications used in children are typically modified from pharmaceutical dosage forms designed for adults. Captopril is widely adapted to liquid formulations for use in hospitals. Its stability in the aqueous medium is reduced since it undergoes oxidation producing captopril disulfide (its main metabolite). The aim of this formulation study was to suggest favorable conditions for the development of a stable captopril formulation. The compatibility between the drug and excipients was evaluated by differential scanning calorimetry analysis (DSC). For studies in solution, different formulations were prepared according to a factorial design varying EDTA concentration, water purity and pH. The resultant formulations were stored at 60°C and analyzed... Tipo: Info:eu-repo/semantics/article Palavras-chave: Pediatric Formulation; Captopril/ pharmacokinetics; Thermal Analysis; Degradation Kinetics; Drug Stability; Drug Compounding/ utilization; Drug Utilization; Excipients/ pharmacokinetics; Dosage Forms; Drug Dosage Calculations; Kinetics; Enzyme Stability/drug effects. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100603 Registros recuperados: 2 Primeira ... 1 ... Última

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