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| Sanna,Daria; Pala,Maria; Cossu,Piero; Dedola,Gian Luca; Melis,Sonia; Fresu,Giovanni; Morelli,Laura; Obinu,Domenica; Tonolo,Giancarlo; Secchi,Giannina; Triunfo,Riccardo; Lorenz,Joseph G.; Scheinfeldt,Laura; Torroni,Antonio; Robledo,Renato; Francalacci,Paolo. |
| We report a sampling strategy based on Mendelian Breeding Units (MBUs), representing an interbreeding group of individuals sharing a common gene pool. The identification of MBUs is crucial for case-control experimental design in association studies. The aim of this work was to evaluate the possible existence of bias in terms of genetic variability and haplogroup frequencies in the MBU sample, due to severe sample selection. In order to reach this goal, the MBU sampling strategy was compared to a standard selection of individuals according to their surname and place of birth. We analysed mitochondrial DNA variation (first hypervariable segment and coding region) in unrelated healthy subjects from two different areas of Sardinia: the area around the town of... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Breeding units strategy; MtDNA haplogroup distribution; Association studies. |
| Ano: 2011 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000200003 |
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