|
|
|
|
|
| Fu, Z.; Zhou, M.; Zhang, G.; Ren, G.. |
| Our previous studies indicated that recombinant rabies viruses expressing chemokines and cytokines (including GM-CSF) could enhance the immunogenicity by inducing innate immunity and recruiting/activating dendritic cells and B cells. In this study, bacterial flagellin was cloned into the rabies virus genome and recombinant virus rLBNSE-Flic was rescued. To compare the immunogenicity of rLBNSEFlic with recombinant virus expressing GM-CSF (rLBNSE-GMCSF), mice were immunized with each of these recombinant rabies viruses by i.m. or the oral route. The parental virus (rLBNSE) without expression of any foreign molecules was included for comparison. The i.m.-immunized mice were bled at three weeks after the immunization for the measurement of virus neutralizing... |
| Tipo: Info:eu-repo/semantics/article |
|
| Ano: 2013 |
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/229 |
| |
|
|
| Fu, Z.; Huang, J.; Li, G.; Zhang, G.; Zhou, M.. |
| Rabies virus (RABV) is a neurotropic virus that causes fatal disease in humans and animals. Currently there is no cure for rabies once clinical signs appear. It has been hypothesized that once the virus enters the central nervous system (CNS), neutralizing antibodies in the periphery cannot cross the blood– brain barrier (BBB) into the CNS. Previous studies have demonstrated that treatment with live-attenuated RABV via the intracerebral route 5 days after infection with wild-type viruses can lead to the clearance not only the attenuated, but also the wild-type virus. Direct administration of liveattenuated RABV stimulated high levels of neutralization antibodies and enhanced the BBB permeability. However, direct intracerebral administration of... |
| Tipo: Info:eu-repo/semantics/article |
|
| Ano: 2013 |
URL: http://www.revistamvez-crmvsp.com.br/index.php/recmvz/article/view/248 |
| |
|
|
|
