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Protective Effect of Caffeic Acid Phenethyl Ester (CAPE) on Ischemia­Reperfusion Injury in Rat Ovary International Journal of Morphology
Görkem,Ümit; Togrul,Cihan; Sahin,Izzet; Coskun,Bugra; Ozat,Mustafa; Güngör,Tayfun; Deveci,Engin.
The aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE) as a prophylactic agent on ischemia/reperfusion (I/R) injury in the rat ovary. A total of 28 Wistar rats were divided into 4 equal groups: (I) sham, (II) ischemia, (III) ischemia + reperfusion, and (IV) IR + CAPE. In groups I and II, ovary torsion was not performed and no drug was administered. In group III, 1 hour of ischemia and 2 hours of reperfusion were performed and no drug was given. Ovarian tissue concentrations of malondialdehyde were significantly higher in the torsion and detorsion groups compared with the sham and Cape groups (P<0.005). The detorsion group showed preantral ovarian follicles and luteal folicules around the blood vessels and positive...
Tipo: Journal article Palavras-chave: Caffeic acid phenethyl ester; Ischemia­reperfusion injury; Ovary; Rat.
Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100023
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Histopathological and Immunohistochemical Changes in the Amniotic Membrane of Gestational Diabetic Mothers International Journal of Morphology
Togrul,Cihan; Görkem,Ümit; Coskun,Bugra; Nergisli,Cansu Kübra; Güngör,Tayfun; Deveci,Engin.
The aim of this study is to examine the changes in the amniotic membrane diagnosed with gestational diabetes mellitus. In this study, as a control group human amnion membrane from normotensive pregnancies was collected from diabetic women at 28­35 weeks of gestation. Gestational diabetes (n= 6) and normal amnion membrane (n= 6) for a total of 12 units were received. Amniotic membrane thickness was measured (p<0.0001) and it was significantly higher in GDM groups compared to control group. The diameter of the amniotic epithelial cell nuclei was measured (p=0.0022). Gestational diabetes results show that there was weakening between amniotic epithelial cell-cell junction. This study showed that structural changes in epithelial cells of amniotic membrane...
Tipo: Journal article Palavras-chave: Amniotic membrane; Gestational diabetic mothers; Immunohistochemical changes.
Ano: 2017 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100030
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