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| GARRIDO,ROGELIO; LAGOS,NÉSTOR; LATTES,KARINNA; GARCÍA,CARLOS; AZOLAS,RODRIGO; BOCIC,GUNTHER; CUNEO,ALDO; CHIONG,HECTOR; JENSEN,CRISTIAN; HENRÍQUEZ,ANA; FERNÁNDEZ,CRISTIAN. |
| The primary clinical symptom of Paralytic Shellfish Poisoning is acute paralytic illness produced by paralyzing toxins. Paralytic shellfish poison is formed by a mixture of phycotoxins and their toxicity is due to its reversible binding to a receptor site on the voltage-gated sodium channel on excitable cells, thus blocking neuronal transmission. We studied the effect of the gonyautoxin 2/3 epimers by local infiltration in the anal internal sphincter of healthy voluntary adults in order to reduce anal tone. The toxin was injected after prior clinical evaluation, anoscopy and anorectal manometry. Post injection clinical examination, electromyography and anorectal manometry were performed. Resting and voluntary contraction pressures were measured and the... |
| Tipo: Journal article |
Palavras-chave: Gonyautoxin 2/3; Phycotoxins; PSP toxins; Anal sphincter; Anal fissure. |
| Ano: 2004 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000300005 |
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| GARCÍA,CARLOS; PEREIRA,PAULO; VALLE,LUIS; LAGOS,NÉSTOR. |
| Diarrhetic shellfish poisoning (DSP) is a gastrointestinal disease caused by lipid soluble polyether toxins produced by dinoflagellates and accumulated in shellfish. Diarrhetic shellfish poisoning is a worldwide threat to public health and the shellfish industry. To date, only four lipid soluble polyethers have been known as diarrhetic shellfish toxins. Among them, Okadaic acid (OA), Dinophysistoxin 1 (DTX-1, 35-methyl OA), Dinophysistoxin 2 (DTX-2, OA isomers) and Dinophysistoxin 3 (DTX-3, 7-O-acyl-35-methyl OA), all of which have free carboxilic groups. To perform quantitative analysis of DSP toxins in shellfish samples is a requirement, because DSP toxins are endemic in the Chilean mollusks of the southern regions, and although human symptoms of DSP... |
| Tipo: Journal article |
Palavras-chave: DSP toxins; Okadaic acid; Dinophysistoxin-1 (DTX-1); Pyrenyldiazomethane (PDAM); Patagonian fjords; Chile. |
| Ano: 2003 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602003000200007 |
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| GARCÍA,CARLOS; LAGOS,MARCELO; TRUAN,DOMINIQUE; LATTES,KARINNA; VÉJAR,OMAR; CHAMORRO,BEATRIZ; IGLESIAS,VERÓNICA; ANDRINOLO,DARÍO; LAGOS,NÉSTOR. |
| This study reports the data recorded from four patients intoxicated with shellfish during the summer 2002, after consuming ribbed mussels (Aulacomya ater) with paralytic shellfish toxin contents of 8,066 ± 61.37 mg/100 gr of tissue. Data associated with clinical variables and paralytic shellfish toxins analysis in plasma and urine of the intoxicated patients are shown. For this purpose, the evolution of respiratory frequency, arterial blood pressure and heart rate of the poisoned patients were followed and recorded. The clinical treatment to reach a clinically stable condition and return to normal physiological parameters was a combination of hydration with saline solution supplemented with Dobutamine (vasoactive drug), Furosemide (diuretic) and Ranitidine... |
| Tipo: Journal article |
Palavras-chave: Paralytic shellfish poisoning; PSP human intoxication; Chilean fjords. |
| Ano: 2005 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200009 |
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