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Cancer, Photodynamic Therapy and Porphyrin-Type Derivatives Anais da ABC (AABC)
GOMES,ANA T.P.C.; NEVES,MARIA G.P.M.S.; CAVALEIRO,JOSÉ A.S..
ABSTRACT This review has two parts. The first one gives an approach to interdisciplinary studies against cancer carried out by many scientists using porphyrin-type substrates as photosensitizers in PDT. Intensive studies were performed for almost six decades. The successes really started in 1993 with the first formulation patented under the trade name Photofrin, which was immediately approved in several countries to treat certain types of cancer. Photofrin is still used although certain negative features soon became well known. That has motivated the search for better new photosensitizers. Several ones were developed, evaluated and a few of them had clinical approval. This group includes porphyrin derivatives and pro-drugs (aminolevulinic acid and its...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cancer; Photodynamic Therapy; Porphyrins; Chlorins; Related macrocycles.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000300993
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