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| FRANCHI,LEONARDO P.; GUIMARAES,NILZA N.; ANDRADE,LAISE R. DE; ANDRADE,HELOISA H.R. DE; LEHMANN,MAURICIO; DIHL,RAFAEL R.; CUNHA,KENYA S.. |
| Noni, a Hawaiian name for the fruit of Morinda citrifolia L., is a traditional medicinal plant from Polynesia widely used for the treatment of many diseases including arthritis, diabetes, asthma, hypertension and cancer. Here, a commercial noni juice (TNJ) was evaluated for its protective activities against the lesions induced by mitomycin C (MMC) and doxorrubicin (DXR) using the Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster. Three-day-old larvae, trans-heterozygous for two genetic markers (mwh and flr3 ), were co-treated with TNJ plus MMC or DXR. We have observed a reduction in genotoxic effects of MMC and DXR caused by the juice. TNJ provoked a marked decrease in all kinds of MMC- and DXR-induced mutant spots, mainly due... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antigenotoxicity; Doxorrubicin; Mitomycin C; SMART; Noni juice. |
| Ano: 2013 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652013000200585 |
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