|
|
|
|
|
| Leitão,C.B.; Nabinger,G.B.; Krahe,A.L.; Bolson,P.B.; Gerchman,F.; Friedman,R.; Gross,J.L.; Canani,L.H.. |
| The aim of the present study was to analyze the frequency of K121Q polymorphism in the ENPP1 gene of Brazilian subjects according to ethnic origin and to determine its possible association with diabetes mellitus (DM) and/or diabetic complications. A cross-sectional study was conducted on 1027 type 2 DM patients and 240 anonymous blood donors (BD). Ethnicity was classified based on self-report of European and African descent. The Q allele frequency was increased in African descendant type 2 DM patients (KK = 25.9%, KQ = 48.2%, and QQ = 25.9%) and BD (KK = 22.0%, KQ = 53.8%, and QQ = 24.2%) compared to European descendant type 2 DM patients (KK = 62.7%, KQ = 33.3%, and QQ = 4.1%) and BD (KK = 61.0%, KQ = 35.6%, and QQ = 3.4%). However, there was no... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: ENPP1 polymorphism; Ethnicity; Type 2 diabetes mellitus. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000300009 |
| |
|
|
| Gerchman,F.; Zanatta,C.M.; Burttet,L.M.; Picon,P.X.; Lisboa,H.R.K.; Silveiro,S.P.; Gross,J.L.; Canani,L.H.. |
| Ethnicity has been shown to be associated with micro- and macrovascular complications of diabetes in European and North American populations. We analyzed the contribution of ethnicity to the prevalence of micro- and macrovascular complications in Brazilian subjects with type 2 diabetes attending the national public health system. Data from 1810 subjects with type 2 diabetes (1512 whites and 298 blacks) were analyzed cross-sectionally. The rates of ischemic heart disease, peripheral vascular disease, stroke, distal sensory neuropathy, and diabetic retinopathy were assessed according to self-reported ethnicity using multiple logistic regression models. Compared to whites, black subjects [odds ratio = 1.72 (95%CI = 1.14-2.6)] were more likely to have ischemic... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Ethnicity; Diabetes mellitus; Chronic complications. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000800005 |
| |
|
|
|
