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	Provedor de dados BJMBR (3) Autor Gianlorenço,A.C.L. (3) Mattioli,R. (3) Serafim,K.R. (3) Canto-de-Souza,A. (1) Costa Neto,J. (1) Fernandes,C.E.M. (1) Mais... Palavra-chave Emotional memory (2) CREB (1) Cerebellar vermis (1) Cerebellum (1) Chlorpheniramine (1) Elevated plus-maze (1) Emotional memory consolidation (1) H3 (1) Histaminergic system (1) Memory consolidation (1) Mice (1) PCREB (1) Ranitidine (1) VUF-8430 (1) Western blotting (1) Mais... Tipo do documento Info:eu-repo/semantics/article (3) Ano 2019 (1) 2014 (1) 2013 (1) País Brazil (3) Idioma Inglês (3)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 3 Primeira ... 1 ... Última Low-dose thioperamide injected into the cerebellar vermis of mice immediately after exposure to the elevated plus-maze impairs their avoidance behavior on re-exposure to the apparatus BJMBR Costa Neto,J.; Serafim,K.R.; Gianlorenço,A.C.L.; Mattioli,R.. The present study investigated the effect of thioperamide (THIO), an H3 histaminergic receptor antagonist, microinjected into the cerebellar vermis on emotional memory consolidation in male Swiss albino mice re-exposed to the elevated plus-maze (EPM). We implanted a guide cannula into the cerebellar vermis using stereotactic surgery. On the third day after surgery, we performed behavioral tests for two consecutive days. On the first day (exposure), the mice (n=10/group) were exposed to the EPM and received THIO (0.06, 0.3, or 1.5 ng/0.1 µL) immediately after the end of the session. Twenty-four hours later, the mice were re-exposed to the EPM under the same experimental conditions, but without drug injection. A reduction in the exploration of the open arms... Tipo: Info:eu-repo/semantics/article Palavras-chave: Histaminergic system; Cerebellum; H3; Emotional memory; Memory consolidation; Elevated plus-maze. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001100943 Systemic injection of an H4 receptor agonist induces a decrease in CREB and pCREB levels in the cerebellar vermis and prefrontal cortex in mice BJMBR Fernandes,C.E.M.; Serafim,K.R.; Gianlorenço,A.C.L.; Mattioli,R.. Studies have shown that an injection with the histamine H4 receptor agonist VUF-8430 modulates emotional memory processes. In the present study, the aim was to verify if intraperitoneal (ip) injection of VUF-8430 (500 ng/kg) in mice affects the synthesis of proteins required for memory consolidation processes by activating the phosphorylation of CREB (pCREB) in classical structures linked to emotional memory (prefrontal cortex, amygdala, and hippocampus) and the cerebellar vermis, a structure that has also been recently implicated in emotional memory. The results obtained using western blot analysis demonstrated that VUF-8430 induced a decrease in CREB and pCREB levels in the cerebellar vermis and prefrontal cortex, suggesting that this dose impaired the... Tipo: Info:eu-repo/semantics/article Palavras-chave: CREB; PCREB; VUF-8430; Western blotting; Emotional memory; Mice. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019000500603 Effect of histamine H1 and H2 receptor antagonists, microinjected into cerebellar vermis, on emotional memory consolidation in mice BJMBR Gianlorenço,A.C.L.; Serafim,K.R.; Canto-de-Souza,A.; Mattioli,R.. This study investigated the effects of histamine H1 or H2 receptor antagonists on emotional memory consolidation in mice submitted to the elevated plus maze (EPM). The cerebellar vermis of male mice (Swiss albino) was implanted using a cannula guide. Three days after recovery, behavioral tests were performed in the EPM on 2 consecutive days (T1 and T2). Immediately after exposure to the EPM (T1), animals received a microinjection of saline (SAL) or the H1 antagonist chlorpheniramine (CPA; 0.016, 0.052, or 0.16 nmol/0.1 µL) in Experiment 1, and SAL or the H2 antagonist ranitidine (RA; 0.57, 2.85, or 5.7 nmol/0.1 µL) in Experiment 2. Twenty-four hours later, mice were reexposed to the EPM (T2) under the same experimental conditions but they did not receive... Tipo: Info:eu-repo/semantics/article Palavras-chave: Chlorpheniramine; Ranitidine; Cerebellar vermis; Emotional memory consolidation. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000200135 Registros recuperados: 3 Primeira ... 1 ... Última

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