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	Provedor de dados BJPS (1) Autor Arshad,Muhammad (1) Ayub,Khurshid (1) Ejaz,Asma (1) Farooq,Ariba (1) Gilani,Mazhar Amjad (1) Kumar,Anupriya (1) Ninomiya,Ichiya (1) Yar,Muhammad (1) Mais... Palavra-chave Acetylcholinesterase (AChE) (1) Alzheimer's disease (1) Antioxidant compounds (1) Butyrylcholinesterase (BChE) (1) Chronic diseases (1) Computational studies (1) DPPH assay (1) Density Functional Theory (1) Indole derivatives (1) Molecular docking (1) Mais... Tipo do documento Info:eu-repo/semantics/article (1) Ano 2015 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Synthesis and DPPH scavenging assay of reserpine analogues, computational studies and in silico docking studies in AChE and BChE responsible for Alzheimer's disease BJPS Yar,Muhammad; Arshad,Muhammad; Farooq,Ariba; Gilani,Mazhar Amjad; Ayub,Khurshid; Ejaz,Asma; Kumar,Anupriya; Ninomiya,Ichiya. Alzheimer's disease (AD) is a fast growing neurodegenerative disorder of the central nervous system and anti-oxidants can be used to help suppress the oxidative stress caused by the free radicals that are responsible for AD. A series of selected synthetic indole derivatives were biologically evaluated to identify potent new antioxidants. Most of the evaluated compounds showed significant to modest antioxidant properties (IC50 value 399.07 140.0±50 µM). Density Functional Theory (DFT) studies were carried out on the compounds and their corresponding free radicals. Differences in the energy of the parent compounds and their corresponding free radicals provided a good justification for the trend found in their IC50 values. In silico, docking of compounds into... Tipo: Info:eu-repo/semantics/article Palavras-chave: Alzheimer's disease; Antioxidant compounds; Chronic diseases; Density Functional Theory; Molecular docking; Computational studies; DPPH assay; Indole derivatives; Acetylcholinesterase (AChE); Butyrylcholinesterase (BChE). Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100053 Registros recuperados: 1 Primeira ... 1 ... Última

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