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Gomig,Franciane; Galvão,Carolina Weigert; Freitas,Denis Leandro de; Labas,Larissa; Etto,Rafael Mazer; Esmerino,Luiz Antonio; Lima,Marcelo Andrade de; Appel,Marcia Helena; Zanata,Silvio Marques; Steffens,Maria Berenice Reynaud; Nader,Helena Bonciani; Silveira,Rafael Bertoni da. |
Quinolones and fluoroquinolones are widely used to treat uropathogenic Escherichia coli infections. Bacterial resistance to these antimicrobials primarily involves mutations in gyrA and parC genes. To date, no studies have examined the potential relationship between biochemical characteristics and quinolone resistance in uropathogenic E. coli strains. The present work analyzed the quinolone sensitivity and biochemical activities of fifty-eight lactose-negative uropathogenic E. coli strains. A high percentage of the isolates (48.3%) was found to be resistant to at least one of the tested quinolones, and DNA sequencing revealed quinolone resistant determining region gyrA and parC mutations in the multi-resistant isolates. Statistical analyses suggested that... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: ODC; GyrA; ParC; Uropathogenic. |
Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000300753 |
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Magina,Michele Debiasi Alberton; Pietrovski,Evelise Fernades; Gomig,Franciane; Falkenberg,Daniel de Barcellos; Cabrini,Daniela Almeida; Otuki,Michel Fleith; Pizzollati,Moacir Geraldo; Brighente,Inês Maria Costa. |
In order to verify the topical antiinflammatory effect of epicuticular wax from leaves of Eugenia beaurepaireana, it was tested in mice croton oil-induced inflammation. Our findings show that topical application of Eugenia beaurepaireana epicuticular wax was significantly active in inhibiting both oedema (Inhibitory dose 50 % (ID50) = 0.31 (0.26 - 0.39) mg.ear -1, inhibition = 79 ± 6 %) and tissue myeloperoxidase activity (indicative of polymorphonuclear leukocytes influx) (ID50 =0.34 (0.20 - 0.41) mg.ear -1, inhibition = 77 ± 4 %) in mice ear treated with croton oil. Two main compounds were detected on epicuticular wax of E. beaurepaireana. These compounds were identified as α- and β-amyrin by flame ionization detection (GC-FID) and spectroscopic methods... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Eugenia beaurepaireana/pharmacognosy; Α-amyrin; Β-amyrin; Epicuticular wax/antiinflammatory activity; Ear oedema/experimental study. |
Ano: 2009 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502009000100021 |
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