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	Provedor de dados BJID (1) Autor Estrela,Rita de Cássia E. (1) Fleury,Marcos K. (1) Gonçalves,José Carlos Saraiva (1) Kritski,Afrânio L. (1) Oliveira,Martha M. (1) Santos,Eliana Abreu (1) Silva,José Roberto Lapa e (1) Velasque,Luciane S. (1) Mais... Palavra-chave Adverse event (1) Hepatotoxicity (1) Induced liver injury from treatment of tuberculosis (1) Polymorphisms of CYP2E1 and GST (1) Pulmonary tuberculosis (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2019 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Relationship of anti-tuberculosis drug-induced liver injury and genetic polymorphisms in CYP2E1 and GST BJID Santos,Eliana Abreu; Gonçalves,José Carlos Saraiva; Fleury,Marcos K.; Kritski,Afrânio L.; Oliveira,Martha M.; Velasque,Luciane S.; Silva,José Roberto Lapa e; Estrela,Rita de Cássia E.. ABSTRACT Setting: Treatment of tuberculosis (TB) can result in Drug-Induced Liver Injury (DILI) since hepatotoxic metabolites are formed during the biotransformation of isoniazid (INH).DILI can be related to the genetic profile of the patient. Single nucleotide polymorphisms in the CYP2E1 gene and GSTM1 and GSTT1 deletion polymorphisms have been associated with adverse events caused by INH. Objective: To characterize the genetic polymorphisms of CYP2E1, GSTT1 and GSTM1 in TB carriers. Design: This is an observational prospective cohort study of 45 patients undergoing treatment of TB. PCR-RFLP and multiplex-PCR were used. Results: The distribution of genotypic frequency in the promoter region (CYP2E1 gene) was: 98% wild genotype and 2% heterozygous.... Tipo: Info:eu-repo/semantics/article Palavras-chave: Adverse event; Polymorphisms of CYP2E1 and GST; Induced liver injury from treatment of tuberculosis; Hepatotoxicity; Pulmonary tuberculosis. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000600381 Registros recuperados: 1 Primeira ... 1 ... Última

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