|
|
| Wei,X.J.; Han,M.; Yang,F.Y.; Wei,G.C.; Liang,Z.G.; Yao,H.; Ji,C.W.; Xie,R.S.; Gong,C.L.; Tian,Y.. |
| We investigated the biological significance of microRNA-126 (miR-126) expression in patients with atrial fibrillation (AF) and/or heart failure (HF) to examine the possible mechanism of miR-126-dependent AF and development of HF. A total of 103 patients were divided into three groups: AF group (18 men and 17 women, mean age: 65.62±12.72 years), HF group (17 men and 15 women, mean age: 63.95±19.71 years), and HF-AF group (20 men and 16 women, mean age: 66.56±14.37 years). Quantitative real-time PCR was used to measure relative miR-126 expression as calculated by the 2−ΔΔCt method. miR-126 was frequently downregulated in the 3 patient groups compared with controls. This reduction was significantly lower in permanent and persistent AF patients than in those... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: MicroRNA-126; Atrial fibrillation; Heart failure; Heart function indices; N-terminal prohormone brain natriuretic peptide (NT-proBNP). |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015001100983 |
| |
