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| Favero-Filho,L.A.; Borges,A.A.; Grassl,C.; Lopes,A.C.; Sinigaglia-Coimbra,R.; Coimbra,C.G.. |
| Chronic neurodegenerative processes have been identified in the rat forebrain after prolonged survival following hyperthermia (HT) initiated a few hours after transient global ischemia. Since transient global ischemia and ischemic penumbra share pathophysiological similarities, this study addressed the effects of HT induced after recirculation of focal brain ischemia on infarct size during long survival times. Adult male Wistar rats underwent intra-luminal occlusion of the left middle cerebral artery for 60 min followed by HT (39.0-39.5°C) or normothermia. Control procedures included none and sham surgery with and without HT, and middle cerebral artery occlusion alone. Part I: 6-h HT induced at recirculation. Part II: 2-h HT induced at 2-, 6-, or 24-h... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hyperthermia; Ischemic penumbra; Neurodegeneration; Rat focal ischemia. |
| Ano: 2008 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001100014 |
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