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	Provedor de dados Anais da ABC (AABC) (2) Autor Grevelding,Christoph G (2) Beckmann,Svenja (1) Dissous,Colette (1) Leutner,Silke (1) Long,Thavy (1) Palavra-chave Schistosoma mansoni (2) CGMP-dependent protein kinases (cGKs) (1) Cell cycle (1) Gonad development (1) Polo-like kinases (1) Reproduction (1) Serine/threonine (S/T) kinases (1) Signal transduction (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2011 (2) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Characterization of the cGMP-dependent protein kinase SmcGK1 of Schistosoma mansoni Anais da ABC (AABC) Leutner,Silke; Beckmann,Svenja; Grevelding,Christoph G. Schistosomes are trematode parasites and of worldwide medical importance for humans and animals. Growth and development of these parasites require a specific host environment, but also permanent communication processes between the two genders. Accumulating molecular evidence indicates that the responsible interactions are mediated by signal transduction processes. Conserved signaling molecules were identified, and first approaches made for their characterization. However, no representative of the conserved family of cGMP-dependent protein kinases (cGKs) has been described in this parasite yet. Within the Schistosoma mansoni genome data-set we identified cGK homologs, of which one was investigated in more detail in this study. We present the cloning of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Schistosoma mansoni; Signal transduction; CGMP-dependent protein kinases (cGKs); Serine/threonine (S/T) kinases; Gonad development. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000200023 Schistosoma mansoni polo-like kinases and their function in control of mitosis and parasite reproduction Anais da ABC (AABC) Dissous,Colette; Grevelding,Christoph G; Long,Thavy. Polo-like kinases are important regulators of cell cycle progression and mitosis. They constitute a family of conserved serine/threonine kinases which are highly related in their catalytic domains and contain polo boxes involved in protein-protein interactions and subcellular localization. In mammals, five Plks (Plk 1-5) encompass diverse roles in centrosome dynamics, spindle formation, intra S-phase and G2/M checkpoints and DNA damage response. Plk1 is a key positive regulator of mitosis and is overexpressed in various types of cancers. Plk4 is a divergent member of the Plk family, with essential functions in centriole duplication. Homozygous disruption of Plk1 or Plk4 in mice is lethal in embryos. Two Plk members SmPlk1 and SmSak, homologous to Plk1 and... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cell cycle; Polo-like kinases; Reproduction; Schistosoma mansoni. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652011000200022 Registros recuperados: 2 Primeira ... 1 ... Última

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