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| Yorgancilar,Ediz; Tunik,Selcuk; Deveci,Engin; Gun,Ramazan; Bakir,Salih; Kinis,Vefa; Ayaz,Ercan; Topcu,Ismail. |
| The objective of this study was to evaluate the histopathologic effects of systemic use of nicotine on the rat nasal mucosa. Twelve adult Sprague-Dawley rats weighing 180-220 g, were used as experimental animals. The rats were divided into Nicotine and control groups. The rats of Nicotine groups (n=6) were administered 2mg/kg Nicotine sulphate for 28 days. The rats of control group (n=6) were only administered 1,5 ml physiologic saline solution subcutaneously for 28 days. All animals were sacrified at the end of the study and nasal tissue samples were removed and prepared for histologic examination. The sections were stained with Hematoxylin and Eosin (H-E) and Periodic acid-Schiff (PAS) and Trichrome-Masson were observed under light microscope. E-cadherin... |
| Tipo: Journal article |
Palavras-chave: Nicotine; Rat; Nasal mucosa; E-cadherin; Immunohistochemistry. |
| Ano: 2012 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000300010 |
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