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	Provedor de dados BJMBR (4) Autor Gutkowska,J. (4) Antunes-Rodrigues,J. (2) Jankowski,M. (2) McCann,S.M. (2) Mukaddam-Daher,S. (2) Palavra-chave Heart (3) Oxytocin (3) Atrial natriuretic peptide (2) Natriuretic peptides (2) Angiotensin II (1) Brain natriuretic peptide (1) Cardiomyogenesis (1) Guanylyl cyclase (1) Hypertension (1) Imidazoline receptors (1) Moxonidine (1) Nitric oxide (1) Sympathetic nerve activity (1) Vasopressin (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Ano 2014 (1) 2004 (1) 2003 (1) 2000 (1) País Brazil (4) Idioma Inglês (4)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 4 Primeira ... 1 ... Última The role of oxytocin in cardiovascular regulation BJMBR Gutkowska,J.; Jankowski,M.; Antunes-Rodrigues,J.. Studies of body volume expansion have indicated that lesions of the anteroventral third ventricle and median eminence block the release of atrial natriuretic peptide (ANP) into the circulation. Detailed analysis of the lesions showed that activation of oxytocin (OT)-ergic neurons is responsible for ANP release, and it has become clear that activation of neuronal circuitry elicits OT secretion into the circulation, activating atrial OT receptors and ANP release from the heart. Subsequently, we have uncovered the entire functional OT system in the rat and the human heart. An abundance of OT has been observed in the early development of the fetal heart, and the capacity of OT to generate cardiomyocytes (CMs) has been demonstrated in various types of stem... Tipo: Info:eu-repo/semantics/article Palavras-chave: Oxytocin; Natriuretic peptides; Heart; Cardiomyogenesis. Ano: 2014 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000300206 Imidazoline receptors in the heart: a novel target and a novel mechanism of action that involves atrial natriuretic peptides BJMBR Mukaddam-Daher,S.; Gutkowska,J.. Chronic stimulation of sympathetic nervous activity contributes to the development and maintenance of hypertension, leading to left ventricular hypertrophy (LVH), arrhythmias and cardiac death. Moxonidine, an imidazoline antihypertensive compound that preferentially activates imidazoline receptors in brainstem rostroventrolateral medulla, suppresses sympathetic activation and reverses LVH. We have identified imidazoline receptors in the heart atria and ventricles, and shown that atrial I1-receptors are up-regulated in spontaneously hypertensive rats (SHR), and ventricular I1-receptors are up-regulated in hamster and human heart failure. Furthermore, cardiac I1-receptor binding decreased after chronic in vivo exposure to moxonidine. These studies implied... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sympathetic nerve activity; Imidazoline receptors; Moxonidine; Atrial natriuretic peptide; Brain natriuretic peptide; Hypertension; Heart. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000800015 Oxytocin is a cardiovascular hormone BJMBR Gutkowska,J.; Jankowski,M.; Mukaddam-Daher,S.; McCann,S.M.. Oxytocin (OT), a nonapeptide, was the first hormone to have its biological activities established and chemical structure determined. It was believed that OT is released from hypothalamic nerve terminals of the posterior hypophysis into the circulation where it stimulates uterine contractions during parturition, and milk ejection during lactation. However, equivalent concentrations of OT were found in the male hypophysis, and similar stimuli of OT release were determined for both sexes, suggesting other physiological functions. Indeed, recent studies indicate that OT is involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of cardiovascular functions. It has long been known that OT induces... Tipo: Info:eu-repo/semantics/article Palavras-chave: Oxytocin; Natriuretic peptides; Heart. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600003 Neuroendocrine control of body fluid homeostasis BJMBR McCann,S.M.; Gutkowska,J.; Antunes-Rodrigues,J.. Angiotensin II and atrial natriuretic peptide (ANP) play important and opposite roles in the control of water and salt intake, with angiotensin II promoting the intake of both and ANP inhibiting the intake of both. Following blood volume expansion, baroreceptor input to the brainstem induces the release of ANP within the hypothalamus that releases oxytocin (OT) that acts on its receptors in the heart to cause the release of ANP. ANP activates guanylyl cyclase that converts guanosine triphosphate into cyclic guanosine monophosphate (cGMP). cGMP activates protein kinase G that reduces heart rate and force of contraction, decreasing cardiac output. ANP acts similarly to induce vasodilation. The intrinsic OT system in the heart and vascular system augments the... Tipo: Info:eu-repo/semantics/article Palavras-chave: Oxytocin; Vasopressin; Atrial natriuretic peptide; Nitric oxide; Angiotensin II; Guanylyl cyclase. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000200003 Registros recuperados: 4 Primeira ... 1 ... Última

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