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	Provedor de dados BJMBR (2) Autor Haddad,L.A. (2) Barboza Jr.,L.C.M. (1) Bento,R.F. (1) Brasileiro-Filho,G. (1) Fuzikawa,A.K. (1) Lezirovitz,K. (1) Mingroni-Netto,R.C. (1) Oiticica,J. (1) Pena,S.D.J. (1) Strauss,B.E. (1) Zanatta,D.B. (1) da-Cunha-Melo,J.R. (1) Mais... Palavra-chave Cell transplantation (1) Cochlea (1) Colorectal carcinoma (1) DCC (1) Hearing loss (1) Microsatellite (1) Microsatellite instability (1) Ototoxicity (1) P53 (1) Polymerase chain reaction (1) Stem cells (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2016 (1) 1997 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Transplantation and survival of mouse inner ear progenitor/stem cells in the organ of Corti after cochleostomy of hearing-impaired guinea pigs: preliminary results BJMBR Barboza Jr.,L.C.M.; Lezirovitz,K.; Zanatta,D.B.; Strauss,B.E.; Mingroni-Netto,R.C.; Oiticica,J.; Haddad,L.A.; Bento,R.F.. In mammals, damage to sensory receptor cells (hair cells) of the inner ear results in permanent sensorineural hearing loss. Here, we investigated whether postnatal mouse inner ear progenitor/stem cells (mIESCs) are viable after transplantation into the basal turns of neomycin-injured guinea pig cochleas. We also examined the effects of mIESC transplantation on auditory functions. Eight adult female Cavia porcellus guinea pigs (250-350g) were deafened by intratympanic neomycin delivery. After 7 days, the animals were randomly divided in two groups. The study group (n=4) received transplantation of LacZ-positive mIESCs in culture medium into the scala tympani. The control group (n=4) received culture medium only. At 2 weeks after transplantation, functional... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cochlea; Hearing loss; Stem cells; Cell transplantation; Ototoxicity. Ano: 2016 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000400603 Utilization of microsatellites for the analysis of genomic alterations in colorectal cancers in Brazil BJMBR Fuzikawa,A.K.; Haddad,L.A.; da-Cunha-Melo,J.R.; Brasileiro-Filho,G.; Pena,S.D.J.. Two different pathogenetic mechanisms are proposed for colorectal cancers. One, the so-called "classic pathway", is the most common and depends on multiple additive mutational events (germline and/or somatic) in tumor suppressor genes and oncogenes, frequently involving chromosomal deletions in key genomic regions. Methodologically this pathway is recognizable by the phenomenon of loss of heterozygosity. On the other hand, the "mutator pathway" depends on early mutational loss of the mismatch repair system (germline and/or somatic) leading to accelerated accumulation of gene mutations in critical target genes and progression to malignancy. Methodologically this second pathway is recognizable by the phenomenon of microsatellite instability. The distinction... Tipo: Info:eu-repo/semantics/article Palavras-chave: Polymerase chain reaction; Colorectal carcinoma; Microsatellite; P53; DCC; Microsatellite instability. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000800001 Registros recuperados: 2 Primeira ... 1 ... Última

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