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	Provedor de dados Nature Precedings (1) Autor Haixia Liu (1) Mingen Xu (1) Renjie Zhang (1) Ri Yao (1) Xiaohong Wang (1) Yongnian Yan (1) Mais... Palavra-chave Biotechnology (1) Pharmacology (1) Tipo do documento Manuscript (1) Ano 2008 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Establishing a multicellular model by three-dimensional cell-assembly technique for metabolic syndrome Nature Precedings Mingen Xu; Yongnian Yan; Renjie Zhang; Ri Yao; Haixia Liu; Xiaohong Wang. One of the major obstacles in developing multifunctional drugs for the metabolic syndrome (MS) is lack of in vitro models that capture more complex features of the disease. Here we give the first report that establishes an energy metabolic system model using cell-assembly technique which can assemble cells into designated places to form complex three-dimensional structures. Adipose-derived stromal cells were assembled and induced differentiation into adipocytes and endothelial cells; pancreatic islets were then deposited at designated locations and constituted adipoinsular axis with adipocytes. Analysis of the factors involved in energy metabolism showed our system could capture more physiological and pathophysiological features of the in vivo energy... Tipo: Manuscript Palavras-chave: Biotechnology; Pharmacology. Ano: 2008 URL: http://precedings.nature.com/documents/1496/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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