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| Besbes,S.; Hamadou,W.S.; Boulland,M.L.; Youssef,Y.B.; Achour,B.; Regaieg,H.; Khelif,A.; Fest,T.; Soua,Z.. |
| IGH gene rearrangement and IGK-Kde gene deletion can be used as molecular markers for the assessment of B lineage acute lymphoblastic leukemia (B-ALL). Minimal residual disease detected based on those markers is currently the most reliable prognosis factor in B-ALL. The aim of this study was to use clonal IGH/IGK-Kde gene rearrangements to confirm B-ALL diagnosis and to evaluate the treatment outcome of Tunisian leukemic patients by monitoring the minimal residual disease (MRD) after induction chemotherapy. Seventeen consecutive newly diagnosed B-ALL patients were investigated by multiplex PCR assay and real time quantitative PCR according to BIOMED 2 conditions. The vast majority of clonal VH-JH rearrangements included VH3 gene. For IGK deletion, clonal... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: IGH gene; IGK gene; B-ALL minimal residual disease (MRD); RQ-PCR. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000100703 |
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