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	Provedor de dados Nature Precedings (1) Autor Byung-Young Park (1) Dongmin Park (1) Eun kyu Park (1) Hee Lee (1) Hyunhee Lee (1) Jaeho Oh (1) Jong Cheon Hahm (1) Michung Yoon (1) Min-Young Kim (1) Yeonhee Hong (1) Mais... Palavra-chave Pharmacology (1) Tipo do documento Manuscript (1) Ano 2011 (1) País United Kingdom (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Reduction of adipose tissue mass by the angiogenesis inhibitor ALS-L1023 Nature Precedings Michung Yoon; Hyunhee Lee; Yeonhee Hong; Dongmin Park; Jaeho Oh; Byung-Young Park; Hee Lee; Eun kyu Park; Jong Cheon Hahm; Min-Young Kim. Objective: Angiogenesis has been demonstrated to modulate adipogenesis and obesity. This study was undertaken to determine whether the botanical drug ALS-L1023 (ALS), which exhibits antiangiogenic activity, can regulate adipose tissue growth in high-fat-diet-induced obese mice.Materials and Methods: The effects of ALS on angiogenesis and extracellular matrix remodeling were measured using in vitro assays. The effects of ALS on adipose tissue growth was investigated in nutritionally obese mice. Results: ALS inhibited angiogenesis in a concentration-dependent manner in the tube formation assay and the VEGF-induced proliferation assay using human umbilical vein endothelial cells. ALS also suppressed matrix metalloproteinase (MMP) activity in vitro. ALS... Tipo: Manuscript Palavras-chave: Pharmacology. Ano: 2011 URL: http://precedings.nature.com/documents/6256/version/1 Registros recuperados: 1 Primeira ... 1 ... Última

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