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Application of Next-generation Sequencing in Clinical Molecular Diagnostics BABT
Seifi,Morteza; Ghasemi,Asghar; Raeisi,Sina; Heidarzadeh,Siamak.
ABSTRACT Next-generation sequencing (NGS) is the catch all terms that used to explain several different modern sequencing technologies which let us to sequence nucleic acids much more rapidly and cheaply than the formerly used Sanger sequencing, and as such have revolutionized the study of molecular biology and genomics with excellent resolution and accuracy. Over the past years, many academic companies and institutions have continued technological advances to expand NGS applications from research to the clinic. In this review, the performance and technical features of current NGS platforms were described. Furthermore, advances in the applying of NGS technologies towards the progress of clinical molecular diagnostics were emphasized. General advantages and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bioinformatics; Clinical molecular applications; Ethical aspects; Next generation sequencing.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100303
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