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Stability-indicating liquid chromatographic and UV spectrophotometric methods for the quantification of ciprofibrate in capsules and tablets BJPS
Hellwig,Fernanda Macke; Reis,Rafael Henrique Dias; Barbosa,Suzana Del Rosso; Malesuik,Marcelo Donadel.
This study describes the development and evaluation of stability-indicating liquid chromatographic (LC) and UV spectrophotometric methods for the quantification of ciprofibrate (CPF) in tablets and capsules. Isocratic LC separation was achieved on a RP18 column using a mobile phase of o-phosphoric acid (0.1% v/v), adjusted to pH 3.0 with triethylamine (10% v/v) and acetonitrile (35:65 v/v), with a flow rate of 1.0 mL min-1. Detection was achieved with a photodiode array detector at 233 nm. For the spectrophotometric analysis, ethanol and water were used as the solvent and a wavelength of 233 nm was selected for the detection. The methods were validated according to International Conference on Harmonization (ICH) guidelines for validating analytical...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ciprofibrate/tablets/quality control; Ciprofibrate/capsules/quality control; UV Spectrophotometry/quantitative analysis; Liquid chromatography/stability study; Medicines/quality control.
Ano: 2015 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100221
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