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Idrees,Muhammad; Siddiqi,Abdul Rauf; Ajmal,Muhammad; Akram,Muhammad; Khalid,Rana Rehan; Hussain,Alamdar; Qamar,Raheel; Bokhari,Habib. |
Abstract Paraoxonase 1 (PON1) is a serum enzyme associated with high density lipoprotein (HDL) regulation through its paraoxonase and arylesterase activity. PON1 inhibits the oxidation of HDL and low density lipoprotein (LDL), and is involved in the pathogenesis of a variety of diseases including atherosclerosis. Conversely, mutations in the low density lipoprotein receptor (LDLR) result in failure of receptor mediated endocytosis of LDL leading to its elevated plasma levels and onset of familial hypercholesterolemia (FH). In the current study we investigated the role of PON1 polymorphisms rs662; c.575A > G (p.Gln192Arg) and rs854560; c.163T > A (p.Leu55Met) in a large family having FH patients harboring a functional mutation in LDLR. Genotypes were... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Paraoxonase-1; Hypercholesteremia; Arylesterase; LDLR mutation. |
Ano: 2018 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018000400570 |
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Raja,Sadaf Azad; Abbas,Seher; Shah,Syed Tahir Abbas; Tariq,Aamira; Bibi,Nazia; Yousuf,Arzu; Khawaja,Athar; Nawaz,Muhammad; Mehmood,Arshad; Khan,Muhammad Jadoon; Hussain,Alamdar. |
Abstract Gene expression is tightly regulated in time and space through a multitude of factors consisting of signaling molecules. Soluble N-ethylmaleimide-sensitive-factor attachment protein receptors (SNARE) are membrane proteins responsible for the intercellular trafficking of signals through endocytosis and exocytosis of vesicles. Altered expression of SNARE proteins in cellular communication is the major hallmark of cancer phenotypes as indicated in recent studies. SNAREs play an important role in maintaining cell growth and epithelial membrane permeability of the bladder and are not only involved in cancer progression but also metastatic cell invasion through SNARE-mediated trafficking. Synaptobrevin2/Vesicle associated membrane protein-2 (v-SNARE)... |
Tipo: Info:eu-repo/semantics/article |
Palavras-chave: SNARE; Bladder cancer; Vesicle fusion; Gene expression. |
Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572019000100040 |
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