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	Provedor de dados Biol. Res. (2) Autor ITURRIAGA,RODRIGO (2) DEL RÍO,RODRIGO (1) REY,SERGIO (1) Palavra-chave Carotid body (2) Chemoreceptor (1) Chemosensory activity (1) Cytochrome oxidase (1) Hypoxia (1) Intermittent hypoxia (1) Nitric oxide (1) Obstructive sleep apnea (1) Oxidative phosphorylation (1) Ventilatory acclimatization (1) Mais... Tipo do documento Journal article (2) Ano 2005 (1) 2001 (1) País Chile (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Nitric oxide and carotid body chemoreception Biol. Res. ITURRIAGA,RODRIGO. Nitric oxide (NO) has been proposed as an inhibitory modulator of carotid body chemosensory responses to hypoxia. It is believed that NO modulates carotid chemoreception by several mechanisms, which include the control of carotid body vascular tone and oxygen delivery and reduction of the excitability of chemoreceptor cells and petrosal sensory neurons. In addition to the well-known inhibitory effect, we found that NO has a dual (dose-dependent) effect on carotid chemoreception depending on the oxygen pressure level. During hypoxia, NO is primarily an inhibitory modulator of carotid chemoreception, while in normoxia NO increased the chemosensory activity. This excitatory effect produced by NO is likely mediated by an impairment of mitochondrial electron... Tipo: Journal article Palavras-chave: Carotid body; Chemoreceptor; Cytochrome oxidase; Hypoxia; Nitric oxide; Oxidative phosphorylation. Ano: 2001 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200019 Cardiovascular and ventilatory acclimatization induced by chronic intermittent hypoxia: A role for the carotid body in the pathophysiology of sleep apnea Biol. Res. ITURRIAGA,RODRIGO; REY,SERGIO; DEL RÍO,RODRIGO. Patients with obstructive sleep apnea (OSA) show augmented ventilatory, sympathetic and cardiovascular responses to hypoxia. The facilitatory effect of chronic intermittent hypoxia (CIH) on the hypoxic ventilatory response has been attributed to a potentiation of the carotid body (CB) chemosensory response to hypoxia. However, it is a matter of debate whether the effects induced by CIH on ventilatory responses to hypoxia are due to an enhanced CB activity. Recently, we studied the effects of short cyclic hypoxic episodes on cat cardiorespiratory reflexes, heart rate variability, and CB chemosensory activity. Cats were exposed to cyclic hypoxic episodes repeated during 8 hours for 4 days. Our results showed that CIH selectively enhanced ventilatory and... Tipo: Journal article Palavras-chave: Ventilatory acclimatization; Carotid body; Chemosensory activity; Intermittent hypoxia; Obstructive sleep apnea. Ano: 2005 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000400004 Registros recuperados: 2 Primeira ... 1 ... Última

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