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Neuropeptide Y signaling in the dorsal raphe nucleus inhibits male sexual behavior in mice OAK
Inaba, A.; Komori, Y.; Muroi, Y.; Kinoshita, K.; Ishii, T..
Animals change their biological activities depending on their nutritional state. Reproductive functions, including sexual behavior, are suppressed under low-energy conditions; however, the underlying neuronal mechanism is poorly understood. Neuropeptide Y (NPY) is an orexigenic molecule released in response to low-energy conditions and has an inhibitory effect on sexual behavior. We examined how NPY is involved in energy state-dependent regulation of male sexual behavior. Mounting, intromission, and ejaculation were evaluated as parameters of sexual behavior. Almost all parameters indicated that fasting for 24 h suppressed male sexual behavior. Intracerebroventricular injection of NPY inhibited sexual behavior in males that free-fed for 8 h following 24-h...
Palavras-chave: Male sexual behavior; Neuropeptide Y; Dorsal raphe nucleus; Serotonin.
Ano: 2016 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4445
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