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| Artigas,Rody; Iriarte,Wanda; de Soto,Leticia; Iriarte,Andrés; Llambí,Silvia; de Bethencourt,Miguel; Postiglioni,Alicia. |
| La translocación Robertsoniana (rob1; 29) está ampliamente distribuida en razas comerciales y en reservas genéticas de bovinos Criollos americanos. Se ha descrito un enlentecimiento en el desarrollo de embriones portadores de esta aneuploidía, frente a embriones normales. La acción de la 5-aza-C, como agente desmetilante, permitiría descondensar la heterocromatina constitutiva o facultativa. En este trabajo se realiza inducción con el análogo de base 5-aza-C(10mM, 2 hrs) en cultivos linfocitarios de una hembra y un macho portadores de la rob1; 29, frente a bovinos Criollos normales. Se controla la acción desmetilante del inductor al identificar la despiralización del cromosoma X de replicación tardía en hembras y permitir el análisis de la despiralización... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 5-azacitidina-C; Descondensación; Rob1; 29; Bovino Criollo. |
| Ano: 2008 |
URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-28122008000100010 |
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| Grasso,Andrés N; Goldberg,Virginia; Navajas,Elly A; Iriarte,Wanda; Gimeno,Diego; Aguilar,Ignacio; Medrano,Juan F; Rincón,Gonzalo; Ciappesoni,Gabriel. |
| The aim of this study was to investigate the genetic diversity within and among three breeds of sheep: Corriedale, Merino and Creole. Sheep from the three breeds (Merino n = 110, Corriedale n = 108 and Creole n = 10) were genotyped using the Illumina Ovine SNP50 beadchip®. Genetic diversity was evaluated by comparing the minor allele frequency (MAF) among breeds. Population structure and genetic differentiation were assessed using STRUCTURE software, principal component analysis (PCA) and fixation index (F ST). Fixed markers (MAF = 0) that were different among breeds were identified as specific breed markers. Using a subset of 18,181 single nucleotide polymorphisms (SNPs), PCA and STUCTURE analysis were able to explain population stratification within... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Allele frequencies breed composition; Fixation index; Ovine SNP50; Population stratification; Principal component analysis. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572014000300011 |
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