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| Chaichanan,Jirapan; Wiyakrutta,Suthep; Pongtharangkul,Thunyarat; Isarangkul,Duangnate; Meevootisom,Vithaya. |
| To optimize the medium for high zofimarin production, sucrose maltose, glucose, tryptone and peptone were used in an orthogonal array design experiment, where the highest value of zofimarin produced was 25.6 µg/mL. This value was about 3 times higher than that obtained with Czapek yeast extract (CzYE) culture medium. A study with Plackett-Burman design showed that sucrose, maltose, glucose and NaNO3 were significant factors in zofimarin production. Further studies using central composite design (CCD) showed the significance of glucose and the interactions of these critical components affecting zofimarin production. Multiple regression analysis of the data yielded a poor fit as shown by the mismatch of the model with these variable factors. When a... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Zofimarin; Secondary metabolite; Medium optimization; Statistical methods; Endophytic fungus. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000100042 |
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