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| Pancrace, Claire; Ishida, Keishi; Briand, Enora; Pichi, Douglas Gatte; Weiz, Annika R.; Guljarnow, Arthur; Scalvenzi, Thibault; Sassoon, Nathalie; Hertweck, Christian; Dittmann, Elke; Gugger, Muriel. |
| The cyanobacterial genus Microcystis is known to produce an elaborate array of structurally unique and biologically active natural products, including hazardous cyanotoxins. Cytotoxic aeruginoguanidines represent a yet unexplored family of peptides featuring a trisubstituted benzene unit and farnesylated arginine derivatives. In this study, we aimed at assigning these compounds to a biosynthetic gene cluster by utilizing biosynthetic attributes deduced from public genomes of Microcystis and the sporadic distribution of the metabolite in axenic strains of the Pasteur Culture Collection of Cyanobacteria. By integrating genome mining with untargeted metabolomics using liquid chromatography with mass spectrometry, we linked aeruginoguanidine (AGD) to a... |
| Tipo: Text |
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| Ano: 2019 |
URL: https://archimer.ifremer.fr/doc/00481/59277/62216.pdf |
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