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Alterations in the Transcriptional Profile of the Liver Tissue and the Therapeutic Effects of Propolis Extracts in Alcohol-induced Steatosis in Rats Anais da ABC (AABC)
YE,MANHONG; XU,MENGTING; JI,CHAO; JI,JIAN; JI,FUBIAO; WEI,WANHONG; YANG,SHENGMEI; ZHOU,BIN.
Abstract Abstract: The hepatoprotective effects of the ethanolic extracts of propolis (EEP) on alcohol-induced liver steatosis were investigated in Wistar rats. Chronic alcoholic fatty liver was induced by administration of 52% alcohol to male Wistar rats at the dose of 1% body weight for 7 weeks. Then animals were simultaneously treated with 50% ethanol solutions of EEP or normal saline at the dose of 0.1% body weight for 4 further weeks. Serological analyses and liver histopathology studies were performed to investigate the development of steatosis. Microarray analysis was conducted to investigate the alterations of hepatic gene expression profiling. Our results showed that 4-week treatment of EEP helped to restore the levels of various blood indices,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fatty acid oxidation; Hepatoprotective effects; Lipogenesis; Propolis extracts; Steatosis.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500610
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