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| SILVA,NATHALIA A.; ALBUQUERQUE,CLEIDE M.R.; MARINHO,ALINE D.; JORGE,ROBERTA J.B.; SILVA NETO,ANTONIO G.; MONTEIRO,HELENA S.A.; SILVA,TÚLIO D.; SILVA,MÁRCIA V.; CORREIA,MARIA TEREZA S.; PEREIRA,TICIANA P.; MARTINS,ALICE M.C.; MENEZES,DALGIMAR B.; XIMENES,RAFAEL M.; MARTINS,RENÉ D.. |
| ABSTRACT Scorpions belonging to the Tityus genus are of medical interest in Brazil. Among them, Tityus stigmurus is the main scorpion responsible for stings in the Northeast region. After a sting, the scorpion venom distributes rapidly to the organs, reaching the kidneys quickly. However, there are few studies concerning the renal pathophysiology of scorpion poisoning. In this study, we evaluated the effects of T. stigmurus venom (TsV) on renal parameters in isolated rat kidneys. Wistar rats (n = 6), weighing 250-300 g, were perfused with Krebs-Henseleit solution containing 6 g/100 mL bovine serum albumin. TsV at 0.3 and 1.0 μg/mL was tested, and the effects on perfusion pressure (PP), renal vascular resistance (RVR), urinary flow (UF), glomerular... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: 2D-PAGE; Kidney; MDCK; Venom; Tityus stigmurus. |
| Ano: 2016 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000200665 |
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